Related Experiment Video
Updated: Jul 1, 2026
08:26
Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
Calcium phosphate-based remineralization systems: scientific evidence?
1Centre for Oral Health Science, School of Dental Science, The University of Melbourne, Victoria. e.reynolds@unimelb.edu.au
Australian Dental Journal
|September 11, 2008
Summary
Calcium phosphate systems like CPP-ACP and Enamelon show promise for remineralizing early dental caries. These technologies may help slow caries progression and promote lesion regression as adjunctive fluoride therapy.
Area of Science:
- Dental Science
- Biomaterials
- Public Health
Background:
- Dental caries is a persistent public health issue despite fluoride's success.
- Current research focuses on early caries detection and non-invasive treatments.
- Remineralization, using calcium and phosphate ions to form fluorapatite, is key for non-invasive caries management.
Purpose of the Study:
- To review scientific evidence for calcium phosphate-based remineralization systems in treating early caries lesions non-invasively.
- To evaluate the efficacy of commercially available systems: CPP-ACP (Recaldent), ACP (Enamelon), and NovaMin.
Main Methods:
- Systematic review of scientific literature.
- Analysis of randomized, controlled clinical trials on remineralization technologies.
Main Results:
- Evidence supports Enamelon's efficacy for root caries.
- Recaldent technology demonstrated significant slowing of coronal caries progression and lesion regression in clinical trials.
- Calcium phosphate systems show potential as adjuncts to fluoride therapy.
Conclusions:
- Calcium phosphate-based remineralization systems show promise for non-invasive early caries management.
- CPP-ACP and Enamelon technologies have demonstrated anticariogenic effects.
- These systems may enhance the effectiveness of traditional fluoride therapy.
More Related Videos
Related Concept Videos
01:31Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
01:27Roles of Electrolytes: Calcium and Phosphate
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
The calcium concentration in blood plasma is primarily regulated...
04:01Factors Affecting Solubility
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
01:22Phosphate Buffer
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:21Skeleton and Calcium Homeostasis
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.