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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Allergy: a risk factor for suicide?

Teodor T Postolache1, Hirsh Komarow, Leonardo H Tonelli

  • 1Teodor T. Postolache, MD Mood and Anxiety Program (MAP), Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building Room 930, Baltimore, MD 21201, USA. tpostolache@psych.umaryland.edu.

Current Treatment Options in Neurology
|September 11, 2008
PubMed
Summary
This summary is machine-generated.

Allergic rhinitis is linked to higher rates of depression, anxiety, and sleep issues. Aeroallergen exposure may worsen these suicide risk factors, especially in spring, suggesting a connection between allergies and suicide risk.

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Patients with allergic rhinitis show higher rates of depression, anxiety, and sleep disturbances compared to the general population.
  • Conversely, individuals with depression exhibit a higher prevalence of allergies.
  • Preliminary data indicate a potential link between a history of allergies and an increased suicide rate.

Purpose of the Study:

  • To investigate the association between aeroallergen exposure and behaviors related to suicide risk.
  • To explore the potential role of allergy-related immune responses in the brain's affective and behavioral centers.
  • To examine the influence of allergy medications on suicide risk factors.

Main Methods:

  • Research in Brown Norway rats involving sensitization and exposure to aeroallergens.
  • Analysis of helper T-cell type 2 (Th2) cytokine gene expression in the prefrontal cortex of rats.
  • Review of existing literature and clinical observations regarding allergies, mental health, and suicide.

Main Results:

  • Aeroallergen sensitization and exposure induced anxiety-like and aggressive behaviors in rats, alongside Th2 cytokine gene expression in the prefrontal cortex.
  • Seasonal peaks in aeroallergens correlate with seasonal peaks in suicide rates.
  • Th2 cytokine expression was found in the orbitofrontal cortex of suicide victims.

Conclusions:

  • Aeroallergen exposure may contribute to seasonal exacerbation of suicide risk factors like anxiety, depression, and sleep disturbance.
  • Allergic inflammation mediators might influence brain function, affecting mood and behavior.
  • Clinicians should screen for allergies in depressed patients and vice versa, considering medication side effects and potential suicide risks.