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Updated: Jul 1, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
Published on: April 29, 2014
[Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas]
Wei Wu1, Jian-tai He, Jing-de Ruan
1Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Aim:
To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas.
Methods:
The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed.
Results:
The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9.
Conclusion:
The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
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