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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Published on: June 6, 2017

Reverse engineering models of cell cycle regulation.

Attila Csikász-Nagy1, Béla Novák, John J Tyson

  • 1Materials Structure and Modeling Research Group of the Hungarian Academy of Sciences, Budapest, Hungary. csikasz@mail.bme.hu

Advances in Experimental Medicine and Biology
|September 12, 2008
PubMed
Summary
This summary is machine-generated.

This study identifies essential dynamical properties for the cell division cycle control system. It proposes molecular mechanisms involving cyclin-dependent kinases to achieve these properties.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Systems Biology

Background:

  • The cell division cycle is a fundamental biological process.
  • Understanding its regulation is crucial for cell biology and disease research.
  • Cyclin-dependent kinases (CDKs) are key regulators of the eukaryotic cell cycle.

Purpose of the Study:

  • To deduce the necessary dynamical properties of the molecular control system governing cell division.
  • To propose plausible molecular mechanisms, particularly involving CDKs, that fulfill these dynamical requirements.

Main Methods:

  • Theoretical analysis of cell division cycle physiology.
  • Deduction of control system dynamics from basic principles.
  • Biochemical insights into cyclin-dependent kinase function.

Main Results:

  • Identification of essential dynamical properties required for robust cell cycle progression.
  • Hypothesized molecular mechanisms for CDK-based control that ensure these dynamics.
  • A framework for understanding cell cycle regulation at a systems level.

Conclusions:

  • The physiological requirements of the cell division cycle dictate specific dynamical properties for its control system.
  • Cyclin-dependent kinases offer a biochemical basis for achieving these critical dynamical properties.
  • This work provides a systems-level perspective on cell cycle regulation.