Related Experiment Video
Updated: Jul 1, 2026

Electrochemotherapy of Tumours
Published on: December 15, 2008
Importance of contact surface between electrodes and treated tissue in electrochemotherapy
Selma Corovic1, Bassim Al Sakere, Vincent Haddad
1CNRS UMR 8121, Institut Gustave-Roussy, Villejuif, France.
Abstract:
Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the target tissue. For successful therapy the entire target tissue has to be exposed to the local electric field strength above the reversible threshold. The aim of this study is to demonstrate the influence of the contact surface between electrode and treated tissue on the coverage of the tumor tissue by sufficiently high local electric field. The electric field distribution is calculated by means of numerical modeling using finite element method. Numerical results are confirmed with in vivo experiments. We demonstrated that the placement of electrodes giving larger electrode-tissue contact surface leads to improved electrochemotherapy outcome. Our results provide guidance on electrochemotherapy for treatment of protruding cutaneous tumors using parallel plate electrodes.
Related Concept Videos
Processes at Electrodes
Interfacial Electrochemical Methods: Overview
Electrodes: Overview
There are two main types of electrodes in electrochemical cells. The first type, known as the working or indicator electrode, has a potential that is sensitive to the analyte's concentration and reacts to changes in the...
Electroconvulsive Therapy
The Electrical Double Layer
Electrochemical Systems
