Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study.

BMC neurology·2026

Same author

Treatment outcomes in new daily persistent headache in children and adolescents.

Cephalalgia : an international journal of headache·2026

Same author

Patient reported trigger, not the speed of transition to continuous headache, is associated with headache-related disability in children: Results of a cross-sectional clinic-based study.

Cephalalgia : an international journal of headache·2026

Same author

Migraine-associated symptoms change with improvement in youth with migraine: A cohort study.

Cephalalgia reports·2026

Same author

Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study.

Neurology. Genetics·2026

Same author

Headache-associated photophobia is more prevalent during winter: A cross-sectional study from a pediatric headache registry.

Headache·2026

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Obesity in the pediatric headache population: a multicenter study.

Andrew D Hershey¹, Scott W Powers, Timothy D Nelson

¹Cincinnati Children's Hospital Medical Center-Neurology, Cincinnati, OH 45229, USA.

|September 12, 2008

Summary

Pediatric obesity is linked to more frequent and disabling headaches. Weight loss in overweight children can reduce headache frequency over time, highlighting the importance of weight management in pediatric headache care.

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

Area of Science:

Pediatric neurology
Obesity research
Public health

Background:

Headache and obesity are prevalent in children and adults.
Adult studies suggest a link between headache and obesity.
This relationship is under-explored in pediatric populations.

Purpose of the Study:

Examine pediatric obesity prevalence.
Correlate weight with headache frequency and disability.
Assess weight change impact on pediatric headache outcomes.

Main Methods:

Collected data on 913 pediatric patients across 7 centers.
Measured height, weight, age, gender, headache frequency, and disability.
Calculated Body Mass Index (BMI) percentile and tracked changes at 3- and 6-month follow-ups.

Main Results:

Overweight prevalence in the cohort matched the general pediatric population.
BMI percentile correlated with initial headache frequency and disability.
In obese/overweight children, BMI change positively correlated with headache frequency change at follow-up.

Conclusions:

Childhood obesity is associated with increased headache frequency and disability.
Weight loss in overweight children can lead to reduced headaches.
Clinicians should consider patient weight status when managing pediatric headaches.