Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The complexity of the population dynamics of Triatoma brasiliensis in rural north-east Brazil indicated by genetic characterisation.

Memorias do Instituto Oswaldo Cruz·2026

Same author

Paracoccidioidomycosis in Brazil: 25-Year Nationwide Trends in Mortality, Hospitalisations and In-Hospital Deaths of a Neglected Systemic Mycosis.

Tropical medicine & international health : TM & IH·2026

Same author

Individual and household factors associated with tungiasis in a marginalized population in Karamoja, northeastern Uganda.

Tropical medicine and health·2026

Same author

Persistent and Emerging High-Risk Clusters of Leprosy Detection in Brazil: A Nationwide Spatiotemporal Analysis, 2001-2023.

Tropical medicine & international health : TM & IH·2026

Same author

Neglected Mycoses in Brazil: A Population-Based Study of Mortality and In-Hospital Mortality Over 25 Years.

Mycoses·2026

Same author

Veterinarians' knowledge and practices on animal Tungiasis in Bahia State, Northeast Brazil.

Veterinary parasitology, regional studies and reports·2026

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Published on: November 21, 2018

A highly efficacious pediculicide based on dimeticone: randomized observer blinded comparative trial.

Jorg Heukelbach¹, Daniel Pilger, Fabíola A Oliveira

¹Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Brazil. heukelbach@web.de

BMC Infectious Diseases

|September 12, 2008

Summary

Dimeticone, a silicone oil pediculicide, demonstrated superior efficacy and cosmetic acceptability over permethrin for treating head lice infestations in children. Resistance to dimeticone is unlikely due to its physical mode of action.

More Related Videos

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Published on: January 31, 2022

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars

Published on: March 15, 2017

Related Experiment Videos

Last Updated: Jul 1, 2026

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Published on: November 21, 2018

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Published on: January 31, 2022

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars

Published on: March 15, 2017

Area of Science:

Parasitology
Dermatology
Clinical Trials

Background:

Head lice (Pediculus humanus capitis) infestations are a global health concern.
Increasing resistance to conventional pediculicides necessitates novel treatment strategies.
Dimeticone, a silicone oil, is investigated as an alternative treatment.

Purpose of the Study:

To compare the efficacy and safety of a 92% dimeticone product against 1% permethrin lotion for treating head lice.
To evaluate cure rates, itching reduction, and cosmetic acceptability of both treatments.

Main Methods:

A randomized, controlled, observer-blinded clinical trial involving 145 children aged 5-15 years in Brazil.
Participants were temporarily relocated to minimize reinfestation.
Two applications of dimeticone or permethrin were administered seven days apart.

Main Results:

Dimeticone achieved significantly higher cure rates on day 2 (94.5%) and day 9 (97.2%) compared to permethrin (66.7% and 67.6%, respectively).
Itching reduction was similar between groups; however, cosmetic acceptability was significantly better with dimeticone.
Two mild product-related incidents were reported in the dimeticone group.

Conclusions:

The dimeticone product is a safe and highly effective pediculicide for head lice.
Its physical mode of action, disrupting lice oxygen supply, makes resistance development unlikely.
Dimeticone offers a promising alternative to conventional treatments facing resistance issues.