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Quantifying Intermembrane Distances with Serial Image Dilations
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An iterative reconstruction technique for geometric distortion-corrected segmented echo-planar imaging.

Yingbiao Xu1, E Mark Haacke

  • 1Department of Electric and Computer Engineering, McMaster University, Hamilton, Ontario, Canada. am4229@wayne.edu

Magnetic Resonance Imaging
|September 12, 2008
PubMed
Summary

This study introduces a new segmented echo-planar imaging (SEPI) technique for susceptibility-weighted imaging. It effectively corrects phase distortions without extra scans, improving image quality and reducing geometric distortion.

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging (MRI)

Background:

  • Susceptibility-weighted imaging (SWI) is crucial for visualizing brain structures and pathologies.
  • Standard SEPI sequences can suffer from geometric distortions and blurring due to field inhomogeneities.
  • Accurate phase correction is essential for high-quality SWI.

Purpose of the Study:

  • To present a modified interleaved segmented echo-planar imaging (SEPI) sequence for SWI applications.
  • To introduce an efficient phase correction technique for SEPI data.
  • To reduce geometric distortion and blurring in SWI without requiring additional reference scans.

Main Methods:

  • A modified interleaved SEPI sequence with a center-out k-space trajectory was developed.
  • A novel phase correction technique was implemented to address field inhomogeneities.

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  • Iterative phase correction using fast Fourier transform and a low-spatial-frequency phase map was employed.
  • An additional echo was incorporated to facilitate phase map generation without phase unwrapping or reference scans.

    • Main Results:

    • The proposed method effectively reduces geometric distortion in the phase-encoding direction.
    • Blurring caused by echo-to-echo phase changes is significantly diminished.
    • Successful demonstration of the technique in both phantom and human data.
    • The method is particularly beneficial for high-resolution imaging.

    Conclusions:

    • The modified SEPI sequence with center-out trajectory and efficient phase correction offers improved SWI.
    • This technique provides a robust solution for mitigating artifacts in MRI.
    • It enhances image quality for detailed anatomical and pathological visualization.