Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microsurgical clipping of paraclinoid aneurysms: a 12-year single-centre experience with surgical nuances and outcomes.

Neurosurgical review·2026

Same author

Integrated serum and tissue NMR metabolomics with correlation analysis reveals metabolic alterations in gliomas.

Journal of neuro-oncology·2026

Same author

Histological approach and differentiation of Crohn's disease and gastrointestinal tuberculosis: Recommendations from the joint IAPM-ISG-CCFI Working Group.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2026

Same author

Oncocytic adrenocortical carcinomas: A clinicopathological and immunohistochemical review of 14 cases of a rare entity.

Indian journal of pathology & microbiology·2026

Same author

Exploring metabolic signatures in urine using NMR for improved prognosis of gliomas.

Metabolomics : Official journal of the Metabolomic Society·2026

Same author

Utilization of Key Morphologic and Molecular Prognostic and Predictive Parameters in Endometrial Malignancies: A Survey of Gynecologic Pathologists.

International journal of surgical pathology·2026

Same journal

Association of smoking with high-risk characteristics for rupture of unruptured intracranial aneurysms.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

Same journal

A multimodal deepsurv approach: integrating radiomics and clinical factors for brain metastasis survival prediction.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

Same journal

CSF-venous fistula with subdural hematoma in the setting of chronic anticoagulation.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

Same journal

Tumor control and cranial nerve outcomes after Gamma Knife radiosurgery for Glomus jugulare tumors: a systematic review, meta-analysis, and institutional failure pattern analysis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

Same journal

Clinical utility of maximal and minimal intensity projections in T2-weighted MRI for neurosurgical planning.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

Same journal

Clinical and CT perfusion outcomes after direct STA-MCA bypass in moyamoya and non-moyamoya steno-occlusive disease: an Indonesian single-center cohort.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Primary midbrain germinoma.

Samir Kumar Kalra¹, Vivek Kumar Vaid, Awadhesh Kumar Jaiswal

¹Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, 226014, Uttar Pradesh, India.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|September 12, 2008

Summary

This summary is machine-generated.

This case study describes an 11-year-old boy with a rare primary midbrain germinoma. Treatment involved surgery, chemotherapy, and radiotherapy, leading to neurological improvement.

More Related Videos

Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

Published on: May 26, 2023

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Related Experiment Videos

Last Updated: Jul 1, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

Published on: May 26, 2023

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Area of Science:

Neuro-oncology
Pediatric Neurology
Neurosurgery

Background:

Primary midbrain germinomas are exceptionally rare central nervous system tumors.
This report details a unique case in an 11-year-old boy presenting with significant neurological deficits.

Purpose of the Study:

To document an extremely rare case of primary midbrain germinoma.
To highlight the clinical presentation, diagnostic challenges, and management of this rare tumor.

Main Methods:

Clinical case presentation with detailed neurological examination findings.
Diagnostic imaging including MRI to identify the midbrain mass and hydrocephalus.
Surgical intervention: ventriculoperitoneal shunt and suboccipital craniectomy with tumor decompression.
Histopathological diagnosis via biopsy confirming germinoma.
Multimodal treatment including chemotherapy and radiotherapy.

Main Results:

The patient presented with progressive holocranial headache, vomiting, visual blurring, ataxia, and sensory-deficits.
Imaging revealed an enhancing midbrain mass with hydrocephalus.
Surgical decompression and shunt placement led to initial neurological improvement.
Histopathology confirmed a germinoma.
Post-operative chemotherapy and radiotherapy were administered.

Conclusions:

Primary midbrain germinoma is an exceedingly rare pediatric tumor with a challenging diagnosis and management.
Multidisciplinary treatment including surgery, chemotherapy, and radiotherapy is crucial for improving outcomes.
Further research and case reporting are vital for understanding this rare entity.