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Updated: Jul 1, 2026

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
Published on: April 27, 2017
Expression and function of ETA and ETB receptors in SSc
1Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Kerckhoff-Klinik Bad Nauheim, Bad Nauheim, Germany. k.frommer@kerckhoff-klinik.de
Abstract:
Endothelin (ET) receptors are widely expressed within the human body with one of their major functions being regulation of the vascular tone. Pulmonary arterial hypertension and other complications associated with SSc are related to the function and or dysregulation of these receptors. As ET receptors also play a crucial role in SSc, this review will discuss the expression and physiological functions of ET receptors in the human organism, their signalling pathways, the complications of diseases they are associated with and their importance as a therapeutic target in SSc.
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