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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

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Related Experiment Video

Updated: Jul 1, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

High-resolution computed tomography and scleroderma lung disease.

A U Wells1

  • 1Interstitial Lung Disease Unit, Royal Brompton Hospital, Chelsea, London, UK. A.Wells@rbht.nhs.uk

Rheumatology (Oxford, England)
|September 17, 2008
PubMed
Summary
This summary is machine-generated.

High-resolution computed tomography (CT) is crucial for detecting interstitial lung disease in systemic sclerosis (SSc). While CT shows lung changes, ground-glass opacity is not a reliable sign of reversible inflammation.

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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Area of Science:

  • Radiology
  • Pulmonary Medicine
  • Rheumatology

Background:

  • High-resolution computed tomography (CT) is integral to diagnosing interstitial lung disease (ILD) in systemic sclerosis (SSc).
  • CT plays a central role in ILD detection due to limitations of other imaging modalities.
  • Historically, CT findings like ground-glass attenuation were thought to indicate reversible inflammation in SSc.

Purpose of the Study:

  • To evaluate the reliability of ground-glass attenuation on CT as an indicator of reversible alveolitis in SSc.
  • To assess the utility of CT in staging the extent of ILD in SSc.
  • To determine the clinical implications of CT-based staging for disease progression and therapeutic studies.

Main Methods:

  • Review of accumulated evidence on CT findings in SSc-related ILD.
  • Correlation of CT findings (ground-glass attenuation, reticular abnormalities, traction bronchiectasis) with surgical biopsy results.
  • Semi-quantitative estimation of disease extent on CT combined with forced vital capacity (FVC) thresholds for staging.

Main Results:

  • Ground-glass attenuation on CT is common in SSc but does not reliably predict reversible alveolitis.
  • Reversible disease is infrequently found on biopsy, especially when ground glass is associated with reticular abnormalities or traction bronchiectasis.
  • CT is more valuable for staging disease extent, distinguishing limited vs. extensive ILD, which has implications for prognosis and clinical trial enrollment.

Conclusions:

  • Ground-glass attenuation on CT is an unreliable marker for reversible alveolitis in SSc.
  • CT is a valuable tool for assessing the extent of ILD in SSc and staging disease severity.
  • CT-based staging aids in identifying patients at higher risk of lung disease progression, informing clinical management and research.