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Effects of suramin on phagocytes in vitro
13rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
Annals of Hematology
|July 1, 1991
Abstract:
In the therapeutically important range (100-200 micrograms/ml), suramin was found to increase the phagocytic activity of human monocytes (measured by the uptake of Saccharomyces cerevisiae and sensitized sheep red blood cells) in vitro. Suramin itself was a chemotactic signal for monocytes and increased the chemiluminescence of neutrophil granulocytes. Suramin seems to act via the ATP-binding P2 receptors of human phagocytes.