Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between phospholipids and biocompatible polymers containing a phosphorylcholine moiety.

M Kojima1, K Ishihara, A Watanabe

  • 1Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.

Biomaterials
|March 1, 1991
PubMed
Summary

Methacryloyloxyethyl phosphorylcholine copolymers exhibit excellent blood compatibility. They interact strongly with natural phospholipids, forming organized layers that prevent platelet aggregation, mimicking natural cell membranes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of glutamate, aspartate and glycine and its potential precursors in human brain using high-performance liquid chromatography by pre-column derivatization with dimethylaminoazobenzene [correction of diethylaminoazobenzene] sulphonyl chloride.

Journal of chromatography·1992
Same author

Extracellular matrix formation in piecemeal necrosis: immunoelectron microscopic study.

Liver·1992
Same author

Obliteration of portal systemic shunts as therapy for hepatic encephalopathy in patients with non-cirrhotic portal hypertension.

Gastroenterologia Japonica·1992
Same author

Hemocompatibility of human whole blood on polymers with a phospholipid polar group and its mechanism.

Journal of biomedical materials research·1992
Same author

[Usefulness of 99mTc-ECD SPECT in diseases of the central nerve system: special reference to a comparison with 123I-IMP and 99mTc-HM-PAO SPECT].

Kaku igaku. The Japanese journal of nuclear medicine·1992
Same author

[The production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with non-insulin dependent diabetes mellitus].

Nihon Jinzo Gakkai shi·1992

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Chemistry

Background:

  • Phospholipid-containing polymers are synthesized for biomaterial applications.
  • Understanding polymer-lipid interactions is crucial for developing biocompatible materials.

Purpose of the Study:

  • To synthesize and characterize copolymers of 2-methacryloyloxyethyl phosphorylcholine and styrene.
  • To investigate the interaction of these copolymers with natural phospholipids (dipalmitoylphosphatidylcholine).
  • To evaluate the blood compatibility of the synthesized copolymers, focusing on platelet aggregation.

Main Methods:

  • Copolymerization of 2-methacryloyloxyethyl phosphorylcholine and styrene.
  • Characterization of amphiphilic properties and micelle formation.

Related Experiment Videos

  • Investigation of dipalmitoylphosphatidylcholine adsorption and liposome stabilization.
  • Assessment of platelet aggregation in vitro.

    • Main Results:

    • Synthesized copolymers exhibited amphiphilic behavior, forming stable micelles.
    • Increased methacryloyloxyethyl phosphorylcholine content enhanced dipalmitoylphosphatidylcholine absorption.
    • Copolymers stabilized dipalmitoylphosphatidylcholine liposome structures.
    • Polymers with methacryloyloxyethyl phosphorylcholine moieties significantly reduced platelet aggregation.

    Conclusions:

    • Methacryloyloxyethyl phosphorylcholine copolymers demonstrate strong affinity for natural phospholipids.
    • These copolymers exhibit excellent blood compatibility, attributed to lipid adsorption and organized layer formation.
    • The biomimetic surface properties contribute to reduced platelet activation.