Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardizing nomenclature in regional anesthesia: an ASRA-ESRA Delphi consensus study of upper and lower limb nerve blocks.

Regional anesthesia and pain medicine·2023
Same author

Incidence of acute compartment syndrome with routine use of regional anesthesia for patients with long bone fractures: a large single-center retrospective review from a level I trauma tertiary academic institution.

Regional anesthesia and pain medicine·2023
Same author

CORR Insights®: Does Preoperative Pharmacogenomic Testing of Patients Undergoing TKA Improve Postoperative Pain? A Randomized Trial.

Clinical orthopaedics and related research·2023
Same author

Empirical guide to a safe thoracic paravertebral block based on dimensions of paravertebral space when ultrasound visualization is challenging.

Regional anesthesia and pain medicine·2023
Same author

Comparing Spinal Chloroprocaine to Hyperbaric and Isobaric Bupivacaine for Total Hip and Knee Arthroplasties: A Retrospective Study.

Cureus·2023
Same author

Effect of Insurance Status on Mortality in Adults With Sarcoma of the Extremities and Pelvis: A SEER-Medicare Study.

The Journal of the American Academy of Orthopaedic Surgeons·2022
Same journal

Phrenic-sparing strategies for shoulder surgery: balancing respiratory safety and block completeness.

Current opinion in anaesthesiology·2026
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
08:05

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Continuous peripheral nerve blockade for postoperative analgesia.

Linda Le-Wendling1, F Kayser Enneking

  • 1Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610-0254, USA. lle@anest.ufl.edu

Current Opinion in Anaesthesiology
|September 12, 2008
PubMed
Summary
This summary is machine-generated.

Continuous peripheral nerve blocks offer superior pain relief and fewer side effects for extremity surgery patients. This method complements multimodal analgesics for moderate to severe postoperative pain management.

More Related Videos

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Related Experiment Videos

Last Updated: Jul 1, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
08:05

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Area of Science:

  • Anesthesiology
  • Pain Management
  • Surgical Recovery

Background:

  • Postoperative pain management remains a critical aspect of surgical recovery.
  • Opioid-based analgesia is associated with significant side effects and addiction potential.
  • Continuous peripheral nerve blocks offer a promising alternative for localized pain control.

Purpose of the Study:

  • To review recent literature on continuous peripheral nerve sheath catheters for postoperative pain.
  • To evaluate the efficacy and safety of continuous peripheral nerve blocks.

Main Methods:

  • Literature review of studies on continuous peripheral nerve sheath catheters.
  • Analysis of data on analgesia, side effects, and complications.
  • Inclusion of studies utilizing ultrasound guidance and different catheter types.

Main Results:

  • Continuous peripheral nerve blocks provide superior analgesia for extremity surgery.
  • These blocks reduce opioid-induced side effects.
  • Ultrasound guidance is increasingly used for placement.
  • Catheter type (stimulating vs. non-stimulating) evidence is equivocal.
  • Major complication rates are very low, comparable to single-injection blocks.

Conclusions:

  • Continuous peripheral nerve blocks are a valuable addition to multimodal analgesia.
  • They effectively manage moderate to severe postoperative pain.
  • This technique enhances patient recovery and reduces opioid reliance.