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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Published on: June 30, 2018

Microalbuminuria: do we need a new threshold?

C R Zamora1, L X Cubeddu

  • 1Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.

Journal of Human Hypertension
|September 12, 2008
PubMed
Summary
This summary is machine-generated.

Lowering the threshold for microalbuminuria (albumin in urine) detection could improve early risk identification for kidney and heart disease. Current guidelines may miss individuals at risk due to higher detection limits.

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Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Risk Assessment

Background:

  • Microalbuminuria (30-300 mg/24h) is a known risk factor for kidney disease, cardiovascular disease, and mortality.
  • Emerging evidence suggests increased risk is present at albuminuria levels below the current microalbuminuria threshold.

Purpose of the Study:

  • To evaluate the significance of lower albuminuria levels as predictors of cardiovascular and renal risk.
  • To propose a revised threshold for microalbuminuria detection.

Main Methods:

  • Review of recent studies examining albuminuria levels and associated health outcomes.
  • Analysis of the predictive value of low-level albuminuria in diverse populations (diabetic, hypertensive, general).

Main Results:

  • Low levels of albuminuria (below 30 mg/24h) independently predict heart disease, death, and hypertension progression.
  • Correction of obesity and metabolic issues can reduce albuminuria to levels (5-7 mg/24h) not associated with increased risk.

Conclusions:

  • The current threshold for microalbuminuria should be lowered significantly (3-4 fold) to capture individuals at increased risk.
  • Clinical guidelines should incorporate lower-rate microalbuminuria as an independent risk factor for early intervention, despite underutilization in practice.