Related Experiment Video
Updated: Jul 1, 2026
Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
Published on: September 27, 2024
[An animal experiment of immediate construction of mandibular defect]
Li-hua Fang1, Jin-liang Ping, Xiang-yong Meng
1Department of Stomatology, Huzhou Central Hospital, uzhou 313000, China. fanglihua9999@126.com
Purpose:
To observe the effect of immediate construction of mandibular defect with or without teeth missing by bone composite and absorbable Bio-gide membrane.
Methods:
40 New Zealand rabbits were randomly divided into 3 groups. For the mandibular defect, group A was filled with nothing, group B was filled with bone composite and Bio-gide membrane, group C was filled with bone composite and Bio-gide membrane as well as autogenous tooth implantation. The rabbits were sacrificed 4,8,12 weeks after surgery for evaluation of gross morphology, X-ray and histopathology.
Results:
After 12 weeks, the defect in group A was still there but narrower, the defect in group B was filled with new bone, the density of which was same to the bone X-ray, and lamellar bone were under microscope, the implanted teeth in group C had been fixed tightly in 17 animals, no transparent areas in 13 animals from X-ray, but absorbable areas in 13 animals under microscope were noted.
Conclusions:
Immediate construction of mandibular defect with bone composite and Bio-guide membrane is feasible and effective,autogeneous tooth implantation on the construction area is also stable.
