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Glial Cells

Glial Cells

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

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Related Experiment Video

Updated: Jul 1, 2026

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

The interface between glial progenitors and gliomas.

Peter Canoll¹, James E Goldman

¹Department of Pathology, Division of Neuropathology, Columbia University, 630 W. 168th St., New York, NY 10032, USA.

Acta Neuropathologica

|September 12, 2008

Summary

This summary is machine-generated.

Glial progenitors in the central nervous system (CNS) may be a source of gliomas. These immature cells share similarities with glioma cells, suggesting a developmental origin for brain tumors.

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Published on: November 17, 2021

Area of Science:

Neuroscience
Developmental Biology
Oncology

Background:

The adult mammalian central nervous system (CNS) harbors diverse populations of immature cells, including stem cells and glial progenitors.
These glial progenitors are abundant in both gray and white matter, representing a significant cellular pool.

Purpose of the Study:

To explore the hypothesis that glial progenitors in the adult CNS are a potential source of gliomas.
To compare the characteristics of normal glial progenitors with those of glioma cells.

Main Methods:

Review of normal glial development and characteristics of glial progenitors.
Comparative analysis of marker phenotypes, morphology, and migratory properties of normal progenitors and glioma cells.
Examination of growth factor responses and known mutational changes in gliomas.

Main Results:

Glioma cells exhibit striking resemblances to glial progenitors in terms of phenotype, morphology, and migration.
Glial progenitors display phenotypic plasticity and respond to growth factors, influencing proliferation and migration.
Mutational changes in gliomas may impact progenitor behavior.

Conclusions:

Glial progenitors are a plausible cell of origin for gliomas.
The cancer stem cell hypothesis may apply to glial progenitors in the context of glioma development.