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Breast malignancy.

H G Bender1, H G Schnürch

  • 1Department of Gynecology and Obstetrics, Frankfurt University Medical Center, Germany.

Current Opinion in Obstetrics & Gynecology
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

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Oral contraceptive risks are higher for young women. Breast cancer screening can reduce mortality, and various treatments are being studied for different stages of the disease.

Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • Oral contraceptive use before age 25 and first pregnancy is linked to increased risks.
  • Breast cancer screening shows potential to reduce mortality in women aged 50-69.
  • Various treatment modalities are under investigation for different breast cancer scenarios.

Purpose of the Study:

  • To review current understanding of risks associated with oral contraceptive use.
  • To explore the effectiveness of chemoprevention strategies.
  • To summarize advancements in breast cancer screening, surgical, and therapeutic interventions.

Main Methods:

  • Literature review of studies on oral contraceptives and breast cancer.
  • Analysis of data on screening effectiveness and mortality reduction.
Keywords:
Age FactorsBiologyBreast Cancer--prevention and controlCancerContraceptionContraceptive MethodsDemographic FactorsDiseasesExaminations And DiagnosesFamily PlanningNeoplasmsOral ContraceptivesPopulationPopulation CharacteristicsRisk FactorsScreeningSurgeryTreatment

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  • Overview of chemoprevention, surgical techniques (lumpectomy), and chemotherapy regimens.
  • Examination of palliative treatments like tamoxifen.
  • Description of methods for analyzing steroid hormone receptor status (fine-needle aspiration, enzyme immunoassay, autoradiography).
  • Identification of prognostic factors under investigation (oncogene amplification, urokinase plasminogen activator, growth factors, proliferation parameters, mutations, cathepsin D).

    • Main Results:

    • Oral contraceptive use before age 25 and first pregnancy is associated with specific risks.
    • Screening may decrease mortality by 30% in women aged 50-69.
    • Breast-conserving lumpectomy is suitable for small tumors.
    • Combined hormonal and chemotherapy may benefit postmenopausal node-positive patients.
    • Dose-intensification of chemotherapy is explored for metastatic breast cancer.
    • Tamoxifen is used for palliative treatment.
    • Multiple methods exist for steroid hormone receptor analysis.
    • Several prognostic factors are under active investigation.

    Conclusions:

    • Early oral contraceptive use poses risks.
    • Screening significantly impacts breast cancer mortality.
    • Treatment strategies are diverse, ranging from surgery to chemotherapy and palliative care.
    • Accurate prognostic factor analysis is crucial for tailoring treatment and improving outcomes.