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Updated: Jul 1, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
[Protein C system in patients with idiopathic pulmonary fibrosis--preliminary report]
Anna Kiziewicz1, Ewa Zekanowska, Krzysztof Cieśliński
1Zakład Zaburzeń Hemostazy, Katedra Patofizjologii Collegium Medicum im, Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikolaja Kopernika w Toruniu, ul. M. Skladowskiej-Curie 9, Bydgoszcz. kizpatofiz@cm.umk.pl
Introduction:
The natural anticoagulant-activated protein C system plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The purpose of this study was to evaluate the concentration of protein C (PC), protein S (PS), thrombomodulin (TM), selectin E (sSelE), and thrombin-antithrombin complex (TAT) in patients with idiopathic pulmonary fibrosis (IPF).
Material And Methods:
Study group consisted of 11 patients aged 51.5 +/- 8.62 years with idiopathic pulmonary fibrosis and 20 healthy adults as control. Concentration of PC, PS TM, sSelE and TAT in plasma with ELISA method was assessed.
Results:
We observed significantly lower plasma concentration of PC (98.24 +/- 16.17% vs. 130.59 +/- 19.03%), PS (71.31 +/- +/- 12.95% vs. 93.47 +/- 18.63%), TM (2.67 +/- 0.40 ng/ml vs. 3.99 +/- 1.16 ng/ml) and significantly higher level of TAT complex (Me = 4.00 mg/ml vs. 2.20 mg/ml) and sSelE (Me = 36.40 ng/ml vs. 22.84 ng/ml) in patients with idiopathic pulmonary fibrosis as compared to controls.
Conclusion:
In presented pilot study we observed decreased activity of protein C system and increased thrombin generation in peripheral blood of patients with idiopathic pulmonary fibrosis.
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