Related Experiment Videos
Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems
E M van Bommel1, M Raghoebar, J J Tukker
1Pharmaceutical Development Department, Duphar BV, Weesp, The Netherlands.
Biopharmaceutics & Drug Disposition
|July 1, 1991
Abstract:
An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled-release system, the Gradient Matrix System (GMS-1 and GMS-2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter-subject variability. GMS-1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time-scaling of the release data.