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[Expression of proline-rich tyrosine kinase-2 in human primary colorectal carcinoma and its prognostic implication]
Zong-nai Zhang1, Xin Wang, Ting Li
1Department of General Surgery, First Hospital, Peking University, Beijing 100034, China.
Objective:
To investigate the expression of proline-rich tyrosine kinase-2 (Pyk2) in human primary colorectal carcinoma (CRC) and it's prognostic significance.
Methods:
The expression of Pyk2 was retrospectively examined with immunohistochemistry (IHC) in 108 tissues of primary CRC. The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed.
Results:
The rate of Pyk2 low-expression in CRC was 56.5% (61/108). The expression of Pyk2 correlated significantly to the histological grade (P < 0.05) and the TNM stage (P < 0.05), while no correlation between Pyk2 expression and age, tumor size (P > 0.05). Patients with Pyk2 over-expression had significantly higher 5-year survival rate (66.0%) than those with Pyk2 low-expression (31.4%). Pyk2 expression, together with carcinoma histologic grade and TNM stage were prognostic factors to CRC on the multivariate analysis.
Conclusions:
Pyk2 expression can be a prognostic factor to the CRC patients together with other predictors.
