Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 1, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Cystamine prevents haloperidol-induced decrease of BDNF/TrkB signaling in mouse frontal cortex.

Anilkumar Pillai1, Rajalakshmi Veeranan-Karmegam, Krishnan M Dhandapani

  • 1Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service, Augusta, Georgia 30904, USA. apillai@mail.mcg.edu

Journal of Neurochemistry
|September 13, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Regional Vulnerability Index (RVI) as a Neuroimaging-Based Biomarker for Autism: Associations with Likelihood, Cognition, and Longitudinal Social Outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Proteomic profiling of cytoskeletal interactomes using MT-ID and Act-ID.

bioRxiv : the preprint server for biology·2026
Same author

Water-soluble fullerene derivatives mitigate cranial radiation-induced neuroinflammation and cognitive dysfunction.

Biomedical microdevices·2026
Same author

MAGEB16 as an epigenetic timing regulator linking X-chromosome biology to neurodevelopmental vulnerability in Autism Spectrum Disorder.

EXCLI journal·2026
Same author

Sex-specific mitochondrial alterations in cognitively unimpaired older depressed individuals.

Journal of affective disorders·2026
Same author

Environmental radioactivity and radiological hazard assessment of soil samples from Rajasthan, India.

Environmental geochemistry and health·2026
Same journal

From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function.

Journal of neurochemistry·2026
Same journal

The Golgi as a Microtubule Organiser in Neurons.

Journal of neurochemistry·2026
Same journal

A PARK9 iPSC-Derived Dopaminergic Neuron Model Enables Drug Screening Targeting Autophagy-Lysosome Pathway Dysfunction in Parkinson's Disease.

Journal of neurochemistry·2026
Same journal

Opposing Estrous Cycle-Dependent Norepinephrine and Dopamine Regulation in Response to Methamphetamine.

Journal of neurochemistry·2026
Same journal

Exercise Snacking in Alzheimer's Disease: A Mechanistic Rationale Based on Repeated Exerkine Signaling.

Journal of neurochemistry·2026
Same journal

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex.

Journal of neurochemistry·2026
See all related articles

Cystamine (CYS) protects brain cells from haloperidol (HAL)-induced damage in schizophrenia models. CYS enhances brain-derived neurotrophic factor (BDNF) signaling, offering neuroprotection and potential therapeutic benefits.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial in schizophrenia pathophysiology and treatment response.
  • Antipsychotic drugs, like haloperidol (HAL), can alter BDNF levels, potentially impacting neuropathology.
  • Neuroprotective strategies are essential for improving schizophrenia treatment outcomes.

Purpose of the Study:

  • To investigate cystamine (CYS) as a potential neuroprotective agent against HAL-induced effects in mice.
  • To elucidate the signaling mechanisms underlying CYS's beneficial effects on BDNF, GSH, and Bcl-xl.
  • To evaluate CYS's efficacy in protecting cortical neurons in vitro.

Main Methods:

  • Administered CYS and HAL to mice, assessing BDNF, GSH, and Bcl-xl protein levels in the frontal cortex.

More Related Videos

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

Related Experiment Videos

Last Updated: Jul 1, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

  • Investigated TrkB receptor activation and downstream signaling pathways (Akt, ERK1/2) using Western blotting.
  • Conducted in vitro experiments on mouse cortical neurons, examining cell viability, apoptosis, and BDNF levels.

    • Main Results:

    • CYS increased BDNF protein levels in mouse frontal cortex.
    • CYS co-treatment prevented HAL-induced reductions in BDNF, GSH, and Bcl-xl.
    • CYS activated TrkB signaling, including Akt and ERK1/2 phosphorylation, and protected neurons from HAL-induced damage.

    Conclusions:

    • Cystamine (CYS) demonstrates significant neuroprotective effects against haloperidol-induced neuropathology in preclinical models of schizophrenia.
    • CYS exerts its protective effects via TrkB receptor activation and downstream PI3K/Akt and MAPK/ERK signaling pathways.
    • These findings support the development of CYS-based neuroprotective strategies to enhance schizophrenia treatment.