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Updated: Jul 1, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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Amniocentesis for PPROM management: a feasibility study.

Maxime Lacerte1, Emmanuel Bujold2, François Audibert1

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Université de Montréal, Montreal QC.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|September 13, 2008
PubMed
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Most mothers with premature rupture of membranes would join a study comparing expectant care with amniocentesis-guided management. This approach helps understand patient choices regarding intra-amniotic infection detection.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Care
  • Clinical Trial Acceptability

Background:

  • Current management for premature rupture of membranes (PROM) before 34 weeks involves hospitalization and delivery, potentially increasing neonatal risks like cerebral palsy due to in utero infection.
  • Amniocentesis can detect intra-amniotic infection markers, offering an alternative management strategy.
  • The established management protocol for PROM in Canada warrants re-evaluation due to potential neonatal risks.

Purpose of the Study:

  • To assess the acceptability of a randomized study comparing expectant management versus amniocentesis-based management for PROM.
  • To understand patient motivations and concerns regarding participation in such a clinical trial.

Main Methods:

  • A qualitative study was conducted with 40 patients experiencing PROM between 28 and 34 weeks gestation.

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  • Participants reviewed an information booklet and completed a questionnaire assessing their willingness to join a randomized trial.
  • Patients also rated the importance of various factors influencing their decision-making process.

    • Main Results:

    • Seventy percent (28/40) of patients indicated they would participate in the proposed randomized study.
    • Key motivators for participation included assessing amniotic fluid infection and fetal lung maturity.
    • Concerns about amniocentesis complications, such as fetal trauma and iatrogenic preterm labor, were reasons for refusal.

    Conclusions:

    • A majority of patients with PROM are willing to participate in studies comparing expectant management with amniocentesis-guided approaches.
    • Understanding patient perspectives is crucial for designing and recruiting for clinical trials in high-risk pregnancies.
    • This study provides valuable insights into patient decision-making regarding PROM management strategies.