Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunomodulatory Nanoparticles for Modulating Arthritis Flares.

ACS nano·2023
Same author

Correction to: The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care.

British journal of cancer·2023
Same author

The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care.

British journal of cancer·2023
Same author

Factors associated with self-reported health among New Zealand military veterans: a cross-sectional study.

BMJ open·2022
Same author

Infrared Thermography for Measuring Elevated Body Temperature: Clinical Accuracy, Calibration, and Evaluation.

Sensors (Basel, Switzerland)·2022
Same author

Mānawatia a Matariki!

The New Zealand medical journal·2021

Related Experiment Video

Updated: Jul 1, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

CA-MRSA lesions: what works, what doesn't.

David McBride1

  • 1Department of Family Medicine, University Student Health Services, Boston University, Boston, MA USA. dmcbride@bu.edu

The Journal of Family Practice
|September 13, 2008
PubMed
Summary

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) abscesses require surgical incision and drainage for effective treatment. Antibiotics after the procedure offer minimal benefit, with specific oral options recommended only if healing is delayed.

More Related Videos

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Related Experiment Videos

Last Updated: Jul 1, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Area of Science:

  • Infectious Diseases
  • Surgical Procedures
  • Antimicrobial Resistance

Background:

  • Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant pathogen causing skin and soft tissue infections.
  • Abscesses caused by CA-MRSA necessitate effective management strategies to prevent complications and recurrence.

Purpose of the Study:

  • To evaluate the efficacy of surgical management versus antibiotic therapy for CA-MRSA abscesses.
  • To determine optimal treatment pathways for uncomplicated and complicated CA-MRSA abscesses.

Main Methods:

  • Review of clinical outcomes for patients with CA-MRSA abscesses treated with incision and drainage.
  • Analysis of the impact of post-procedure antibiotic use on healing rates and treatment success.
  • Identification of alternative therapeutic options for cases with delayed healing.

Main Results:

  • Surgical incision and drainage alone achieve high cure rates (≥90%) for CA-MRSA abscesses.
  • Post-procedure antibiotic administration does not substantially improve healing outcomes.
  • Trimethoprim-sulfamethoxazole and tetracycline are effective oral antibiotic choices for persistent infections.

Conclusions:

  • Incision and drainage is the primary and most effective treatment for CA-MRSA abscesses.
  • Routine post-procedure antibiotics are not recommended, simplifying treatment protocols.
  • A defined antibiotic course is reserved for cases failing initial surgical management.