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Retinopathy of prematurity in small-for-gestational age infants compared with those of appropriate size for

C A Dhaliwal1, B W Fleck, E Wright

  • 1Centre for Reproductive Biology, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK. cdhaliwa@staffmail.ed.ac.uk

Archives of Disease in Childhood. Fetal and Neonatal Edition
|September 13, 2008
PubMed

Insights

Small-for-gestational age (SGA) infants show higher rates of retinopathy of prematurity (ROP) and more severe disease compared to appropriate-for-gestational age (AGA) infants. This finding highlights the need for vigilant eye screening in high-risk premature infants.

Area of Science:

  • Neonatal ophthalmology
  • Perinatal medicine
  • Public health

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Small-for-gestational age (SGA) infants represent a vulnerable population with potential for increased ROP risk.
  • Understanding ROP incidence in SGA versus appropriate-for-gestational age (AGA) infants is crucial for targeted screening.

Purpose of the Study:

  • To compare the incidence and severity of ROP between SGA and AGA infants.
  • To evaluate ROP outcomes in premature infants undergoing routine eye screening.
  • To inform ROP screening protocols for high-risk neonates.

Main Methods:

  • Retrospective analysis of eye screening data for infants born <1500 g or <32 weeks gestational age.
  • Comparison of ROP stages (any, severe, treated) between SGA and AGA infants.
  • SGA defined as birth weight below the 10th percentile for gestational age.

Main Results:

  • 23% of 1413 screened infants were SGA.
  • SGA infants (gestational age 26-31 weeks) had significantly higher rates of any ROP (p<0.01).
  • SGA infants showed increased likelihood of severe ROP across gestational age subgroups (p<0.01 to 0.01).

Conclusions:

  • SGA infants are at significantly higher risk for developing ROP and more severe forms of the disease.
  • Findings underscore the importance of ROP screening for SGA infants.
  • This study contributes to understanding ROP disparities in premature infants.
Abstract

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