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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jun 15, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Observations on the physiological interactions between obesity and asthma.

Katina Nicolacakis1, Mary E Skowronski, Albert J Coreno

  • 1Division of Pulmonary, Critical Care, and Sleep Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 13, 2008
PubMed
Summary

Asthma and obesity impact lung function differently, with their respiratory effects adding algebraically rather than interacting synergistically. This suggests distinct pathogenic processes rather than shared mechanisms in comorbid patients.

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Multidisciplinary Approach to Obesity Management: A Case Report
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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Multidisciplinary Approach to Obesity Management: A Case Report

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Area of Science:

  • Respiratory Medicine
  • Pulmonology
  • Pathophysiology

Background:

  • Asthma and obesity are prevalent conditions affecting respiratory health.
  • Understanding shared or distinct pathogenic mechanisms is crucial for managing comorbid asthma and obesity.

Purpose of the Study:

  • To investigate whether asthma and obesity share common pathogenic features impacting lung function.
  • To determine if the physiological effects of asthma and obesity interact synergistically or add algebraically when present together.

Main Methods:

  • Lung function was assessed in normal, asthmatic, obese, and comorbid asthma and obesity groups.
  • Measurements included specific conductance, spirometry, lung volumes, and airway responsiveness.
  • Six-minute walk tests were conducted in subsets of participants.

Main Results:

  • Asthma independently reduced specific conductance and spirometry, increasing airway reactivity and residual volume.
  • Obesity independently reduced spirometry, total lung capacity, and functional residual capacity.
  • Comorbid asthma and obesity showed additive, not synergistic, effects on lung function, with distinct features remaining unchanged.

Conclusions:

  • Asthma and obesity influence the respiratory system through different pathophysiological processes.
  • The combined effects of asthma and obesity on lung function are additive, indicating a lack of shared underlying mechanisms.
  • These findings suggest distinct therapeutic targets for managing comorbid asthma and obesity.