Reference values for neonatal thyroid volumes in a moderately iodine-deficient area

Area of Science:

• Pediatric Endocrinology
• Neonatal Ultrasound
• Thyroidology

Background:

• Thyroid volume reference ranges in neonates are influenced by regional iodine status.
• Previous studies indicate a wide range (0.47-1.62 ml) for neonatal thyroid volumes.
• Bursa city is recognized as a moderately iodine-deficient region.

Purpose of the Study:

• To determine the normal reference ranges for neonatal thyroid volumes in Bursa city.
• To establish local, region-specific reference values for neonatal thyroid assessment.

Main Methods:

• A cross-sectional study involving 100 healthy full-term neonates (51 boys, 49 girls).
• Thyroid volumes were measured using ultrasonography within the first week of life.
• Data were analyzed in relation to gestational age, birth weight, gender, TSH levels, and maternal factors.

Main Results:

• Mean neonatal thyroid volumes were calculated: 0.82±0.18 ml for all neonates, 0.84±0.21 ml for males, and 0.80±0.14 ml for females.
• No statistically significant differences in thyroid volumes were found concerning gestational age, birth weight, gender, TSH values, or maternal factors.
• Mean TSH levels varied between genders, with a statistically significant difference (p=0.006).

Conclusions:

• Normal neonatal thyroid volumes exhibit regional variations.
• Establishing local reference values is crucial for accurate thyroid volume assessment.
• The findings provide valuable reference data for neonatal thyroid volumes in this moderately iodine-deficient region.