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Reference values for neonatal thyroid volumes in a moderately iodine-deficient area

N Köksal1, B Aktürk, H Saglam

  • 1Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Uludag University, 16059 Gorukle, Bursa, Turkey.

Journal of Endocrinological Investigation
|September 13, 2008
PubMed

Insights

Neonatal thyroid volume reference ranges vary by region. This study establishes local values for Bursa city, a moderately iodine-deficient area, using ultrasonography in healthy newborns.

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Ultrasound
  • Thyroidology

Background:

  • Thyroid volume reference ranges in neonates are influenced by regional iodine status.
  • Previous studies indicate a wide range (0.47-1.62 ml) for neonatal thyroid volumes.
  • Bursa city is recognized as a moderately iodine-deficient region.

Purpose of the Study:

  • To determine the normal reference ranges for neonatal thyroid volumes in Bursa city.
  • To establish local, region-specific reference values for neonatal thyroid assessment.

Main Methods:

  • A cross-sectional study involving 100 healthy full-term neonates (51 boys, 49 girls).
  • Thyroid volumes were measured using ultrasonography within the first week of life.
  • Data were analyzed in relation to gestational age, birth weight, gender, TSH levels, and maternal factors.

Main Results:

  • Mean neonatal thyroid volumes were calculated: 0.82±0.18 ml for all neonates, 0.84±0.21 ml for males, and 0.80±0.14 ml for females.
  • No statistically significant differences in thyroid volumes were found concerning gestational age, birth weight, gender, TSH values, or maternal factors.
  • Mean TSH levels varied between genders, with a statistically significant difference (p=0.006).

Conclusions:

  • Normal neonatal thyroid volumes exhibit regional variations.
  • Establishing local reference values is crucial for accurate thyroid volume assessment.
  • The findings provide valuable reference data for neonatal thyroid volumes in this moderately iodine-deficient region.
Abstract

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