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Gluten ataxia
Marios Hadjivassiliou1, David S Sanders, Nicola Woodroofe
1Department of Neurology, The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK. m.hadjivassiliou@sheffield.ac.uk
Gluten ataxia, an immune disorder from gluten, requires early diagnosis. Identifying antigliadin antibodies and IgA deposits aids in managing this condition and preventing progression.
Area of Science:
- Neurology
- Immunology
- Gastroenterology
Background:
- Gluten ataxia is an immune-mediated neurological disorder.
- It is triggered by gluten ingestion in susceptible individuals.
- It presents as idiopathic sporadic ataxia.
Purpose of the Study:
- To highlight gluten ataxia in the differential diagnosis of ataxia.
- To emphasize the importance of early diagnosis and gluten-free diet.
- To discuss reliable diagnostic markers for gluten ataxia.
Main Methods:
- Review of clinical presentation and diagnostic markers.
- Focus on antigliadin antibodies.
- Analysis of IgA deposits against TG2 in the small bowel and extraintestinal sites.
Main Results:
- Antigliadin antibodies are sensitive markers for gluten ataxia.
- IgA deposits against TG2 are reliable and potentially more specific markers.
- These markers may elucidate the pathogenesis of gluten sensitivity.
Conclusions:
- Gluten ataxia should be considered in patients with idiopathic sporadic ataxia.
- Early diagnosis and a gluten-free diet can improve symptoms and halt progression.
- Antigliadin antibodies and TG2 IgA deposits are valuable diagnostic tools.
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