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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

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Related Experiment Video

Updated: Jul 1, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Combination therapy in asthma: a review.

J A Saleh1

  • 1Galbose Hospital, Jimeta-Yola, Adamawa State. jalal.abubakar-saleh03@imperial.ac.uk

Nigerian Journal of Medicine : Journal of the National Association of Resident Doctors of Nigeria
|September 16, 2008
PubMed
Summary

Combination inhalers for asthma improve patient compliance and reduce treatment complexity. Budesonide/formoterol offers effective maintenance and reliever therapy for adults and children.

Area of Science:

  • Respiratory Medicine
  • Pharmacology

Background:

  • Asthma is a chronic airway inflammatory disease with increasing prevalence, particularly in young populations.
  • Inhaled therapies, often combining two medications in one device, are central to asthma management.
  • Current management aims for adjustable maintenance dosing to control symptoms.

Purpose of the Study:

  • To review the efficacy and benefits of combination therapy in asthma management.
  • To evaluate the role of single inhaler devices combining long-acting beta-agonists and inhaled corticosteroids.
  • To assess the potential of combination therapy as both maintenance and reliever treatment.

Main Methods:

  • Literature review of medical journals and reputable health organization websites.
  • Keywords included asthma, combination therapy, long-acting beta-agonists, and corticosteroids.

Related Experiment Videos

Last Updated: Jul 1, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

  • Information sourced from MEDLINE, PubMed, ScienceDirect, and official guidelines.

    • Main Results:

    • Combination therapy with long-acting beta-agonists (LABA) and inhaled corticosteroids (ICS) in a single inhaler shows synergistic effects.
    • This approach enhances patient compliance, simplifies treatment, and reduces disease-related morbidity.
    • Recent findings indicate combination therapy can serve as both maintenance and reliever, matching short-acting beta-agonist (SABA) efficacy.

    Conclusions:

    • Combination therapy offers significant advantages for asthma patients, addressing both inflammatory and bronchoconstrictive aspects.
    • Budesonide/formoterol in a single inhaler is effective and safe for maintenance and reliever therapy in adults and children.
    • These devices promote individualized asthma management, improve convenience, and are suitable for primary care settings.