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Related Experiment Video

Updated: Jul 1, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

[Measures against hyperuricemia].

Iwao Ohno¹, Tatsuo Hosoya

¹Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|September 16, 2008

Summary

This summary is machine-generated.

Hyperuricemia may contribute to hypertension and kidney disease. Allopurinol treatment improved these conditions in patients with chronic kidney disease, but further large-scale studies are needed.

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Last Updated: Jul 1, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Area of Science:

Nephrology
Cardiology
Metabolic Disorders

Background:

Hyperuricemia is increasingly recognized for its potential role in the pathogenesis of hypertension and chronic kidney disease (CKD).
Clinical and animal studies suggest a link between elevated uric acid levels and the development and progression of these conditions.
Allopurinol, a medication used to treat hyperuricemia, has shown promise in improving renal function and hypertension.

Purpose of the Study:

To evaluate the impact of hyperuricemia on the progression of hypertension and renal disease.
To assess the efficacy of allopurinol in managing hypertension and renal function in patients with CKD.
To determine the necessity of treating hyperuricemia in the context of chronic kidney disease.

Main Methods:

Review of existing clinical studies and animal experiments investigating the role of hyperuricemia.
Analysis of patient data from studies involving allopurinol treatment for hyperuricemia in CKD.
Observation of the effects of allopurinol withdrawal on hypertension and renal function in CKD patients.

Main Results:

Evidence suggests hyperuricemia plays a pathogenic role in hypertension and renal disease.
Allopurinol treatment was associated with improvements in hypertension and renal function.
Withdrawal of allopurinol led to worsening hypertension and accelerated renal function decline in CKD patients.

Conclusions:

Hyperuricemia is implicated in the development and progression of hypertension and kidney disease.
Allopurinol may be a beneficial treatment for managing hypertension and preserving renal function in CKD patients.
Further large-scale clinical trials are essential to confirm the necessity and efficacy of treating hyperuricemia in CKD.