Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Phosphoinositides and PIPs

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Primary penile tuberculosis masquerading as penile cancer: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2023

Same author

Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets.

Bioinformation·2023

Same author

Retraction Note: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines.

BMC cancer·2021

Same author

Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19.

Journal of biomolecular structure & dynamics·2020

Same author

A prospective compound screening contest identified broader inhibitors for Sirtuin 1.

Scientific reports·2019

Same author

The crystal structures and Hirshfeld surface analyses of four 3,5-diacetyl-2-methyl-2,3-di-hydro-1,3,4-thia-diazol-2-yl derivatives.

Acta crystallographica. Section E, Crystallographic communications·2019

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA₂

Published on: September 26, 2025

Modeling studies on phospholipase A2-inhibitor complexes.

Nithya Nirmal¹, G Om Praba, D Velmurugan

¹Center of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai - 600 025.

Indian Journal of Biochemistry & Biophysics

|September 16, 2008

Summary

This summary is machine-generated.

Medicinal compounds from plants and marine life inhibit Phospholipase A2 (PLA2), an enzyme linked to inflammation. Molecular modeling confirmed these compounds bind effectively to PLA2 active sites, supporting their anti-inflammatory potential.

More Related Videos

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Published on: September 1, 2023

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)

Published on: February 5, 2022

Related Experiment Videos

Last Updated: Jul 1, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA₂

Published on: September 26, 2025

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Published on: September 1, 2023

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)

Published on: February 5, 2022

Area of Science:

Biochemistry
Pharmacology
Molecular Biology

Background:

Phospholipase A2 (PLA2) enzymes hydrolyze phospholipids, producing arachidonic acid, a precursor to inflammatory eicosanoids.
PLA2 inhibitors are investigated as therapeutic agents for inflammatory diseases.
Natural sources like plants and marine organisms offer potential anti-inflammatory compounds.

Purpose of the Study:

To investigate the structure-function relationship of selected herbal and marine compounds.
To understand the binding mechanisms of these compounds with target PLA2 enzymes.
To provide a molecular basis for the anti-inflammatory properties of these natural products.

Main Methods:

Molecular modeling studies were conducted using Molecular Operating Environment (MOE) software.
Russell's viper PLA2 and bovine pancreatic PLA2 were used as target molecules.
Binding interactions between compounds and PLA2 active sites were analyzed.

Main Results:

Herbal compounds (acalyphin, chlorogenic acid, stigmasterol, curcumin, tectoridin) and marine compounds (gracilin A, aplysulphurin A) were studied.
Favorable interactions were observed between these compounds and the active sites of both Russell's viper and bovine pancreatic PLA2.
The molecular modeling data supports the known anti-inflammatory and antidote efficacies of these compounds.

Conclusions:

Natural compounds from herbal and marine sources exhibit potential as PLA2 inhibitors.
Molecular modeling provides insights into the binding interactions responsible for their anti-inflammatory effects.
These findings validate the therapeutic potential of studied compounds for inflammation-related conditions.