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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Jul 1, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Glomus tumor.

Zoltan Gombos1, Paul J Zhang

  • 1Department of Pathology and Laboratory Medicine, Lafayette General Medical Center, Lafayette, LA 70505, USA. zgombos@lgmc.com

Archives of Pathology & Laboratory Medicine
|September 16, 2008
PubMed
Summary

Glomus tumors are rare benign neoplasms originating from glomus bodies, specialized vascular structures. Misdiagnosis as other vascular lesions complicates prevalence assessment, though a rare malignant form exists.

Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Glomus tumors are rare benign mesenchymal neoplasms, accounting for less than 2% of soft tissue tumors.
  • These tumors arise from glomus bodies, which are specialized arteriovenous anastomoses involved in thermoregulation.
  • Glomus bodies are typically located in the dermal and precoccygeal soft tissues.

Purpose of the Study:

  • To provide a comprehensive overview of glomus tumors.
  • To highlight the diagnostic challenges and potential for misdiagnosis.
  • To discuss the rare malignant counterpart of glomus tumors.

Main Methods:

  • Review of existing literature on glomus tumors.
  • Analysis of histopathological features.
  • Clinical case reviews (implied).

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Main Results:

  • Glomus tumors are characterized by cells resembling modified smooth muscle cells of glomus bodies.
  • Clinical misdiagnosis as hemangiomas or venous malformations is common, hindering accurate prevalence data.
  • A malignant variant of glomus tumor is exceptionally rare.

Conclusions:

  • Accurate diagnosis of glomus tumors is crucial due to potential misdiagnosis.
  • Understanding the origin and characteristics of glomus tumors aids in differential diagnosis.
  • The rarity of malignant glomus tumors warrants specific consideration.