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Cutaneous and systemic plasmacytosis: a Chinese case.

Hui-Jun Ma¹, Wen Liu, You Li

¹Department of Dermatology, The Airforce General Hospital of Chinese People's Liberation Army, Beijing, China. melanocytes@163.com

The Journal of Dermatology

|September 16, 2008

Summary

This report details a rare case of cutaneous and systemic plasmacytosis (CSP) in a Chinese patient. Topical tacrolimus showed temporary improvement in skin lesions, highlighting the condition

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Area of Science:

Dermatology and Immunology
Rare Diseases
Plasma Cell Disorders

Background:

Cutaneous and systemic plasmacytosis (CSP) is an exceptionally rare condition.
CSP predominantly affects individuals of Japanese descent.
This case represents the first documented instance of CSP in mainland China.

Observation:

A 49-year-old Chinese male presented with a 6-year history of asymptomatic brownish-red macules and papules on the face and trunk.
Clinical examination revealed numerous symmetric lesions.
Systemic evaluation identified hypergammaglobulinemia and lymphadenopathy in axillary, paratracheal, and pulmonary regions.

Findings:

Histopathological analysis demonstrated perivascular and periadnexal infiltrates of plasma cells in the dermis.

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Immunohistochemistry confirmed CD20-positive cells among the infiltrates.

The plasma cells were polyclonal and expressed both kappa and lambda light chains.

Implications:

Topical tacrolimus 0.1% provided temporary reduction in lesion thickness and pigmentation.
Lesions recurred after therapy cessation, indicating the need for long-term management strategies.
This case expands the known demographic profile of CSP and underscores the importance of considering this rare condition in diverse populations.