Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contributions to Constructing Forced-Choice Questionnaires Using the Thurstonian IRT Model.

Multivariate behavioral research·2023
Same author

Outcomes and Predictors of Response to Pregabalin for the Treatment of Post-Traumatic Trigeminal Neuropathic Pain Following Neuroablative Procedures: A Retrospective Observational Study.

Pain physician·2023
Same author

Hydrazine-Assisted Acidic Water Splitting Driven by Iridium Single Atoms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023
Same author

A photoelectrochemical aptasensor for tetracycline based on the self-assembly of 2D MoS<sub>2</sub> on a 3D ZnO/Au/ITO electrode.

The Analyst·2023
Same author

Low-Background Signal-On Homogeneous Electrochemiluminescence Biosensor for Hepatitis B Virus Detection Based on the Regulation of the Length of DNA Modified on the Nanoparticles by CRISPR/Cas12a and Hybridization Chain Reaction.

Analytical chemistry·2023
Same author

Neonatal outcomes and related risk factors of 30 cases with aplastic anemia in pregnancy: A retrospective study.

Early human development·2023
Same journal

Macrophage Senescence and Programmed Cell Death in Atherosclerosis: Mechanisms, Cross-Talk, and Emerging Therapeutic Strategies.

Ageing research reviews·2026
Same journal

Amylin at the crossroads of type 2 diabetes and neurodegenerative diseases.

Ageing research reviews·2026
Same journal

Cell death regulation: A novel way of natural products to treat myocardial hypertrophy.

Ageing research reviews·2026
Same journal

Digital technologies for healthy longevity: A policy agenda from the Einstein circle on inclusive, data-driven ageing societies.

Ageing research reviews·2026
Same journal

Molecular and environmental drivers of tau post-translational modifications and tau pathology.

Ageing research reviews·2026
Same journal

From lifespan extension to hallmark-informed gerotherapeutic prioritization: A bibliometric-guided, strategy-oriented review of anti-aging drug research.

Ageing research reviews·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Inflammatory response is associated with aortic dissection.

Fang Luo1, Xian-Liang Zhou, Jian-Jun Li

  • 1Department of Cardiology, FuWai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China.

Ageing Research Reviews
|September 16, 2008
PubMed
Summary
This summary is machine-generated.

Inflammation drives aortic dissection by degrading the aortic artery wall, involving inflammatory cells and biomarkers. Understanding this process offers new avenues for treating this life-threatening cardiovascular disease.

More Related Videos

Murine Model of Thoracic Aortic Dissection Induced by Oral &#946;-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral &#946;-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Pathology

Background:

  • Aortic dissection is a life-threatening cardiovascular disease with high mortality.
  • Inflammation is increasingly recognized as a key factor in its development and progression.

Purpose of the Study:

  • To review the critical role of inflammation in the pathogenesis of aortic dissection.
  • To explore how inflammatory processes inform potential therapeutic strategies.

Main Methods:

  • Review of current literature on inflammation and aortic dissection.
  • Analysis of the involvement of inflammatory cells (lymphocytes, macrophages) and biomarkers.
  • Discussion of imaging techniques like PET/CT for assessing inflammatory activity.

Main Results:

  • Inflammatory cells contribute to medial degradation and smooth muscle cell apoptosis, the principal mechanism of dissection.
  • Systemic inflammatory biomarkers correlate with disease severity, prognosis, and differential diagnosis.
  • Elevated inflammatory activity in the aortic wall is linked to poor clinical outcomes.

Conclusions:

  • Inflammation is central to aortic dissection's development and progression.
  • Targeting inflammatory pathways may offer novel pharmacological treatments for aortic dissection.