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A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
Plasmacytoid dendritic cells mediate oral tolerance.
Anne Goubier1, Bertrand Dubois, Hanane Gheit
1INSERM, U851, 21 Avenue Tony Garnier, Lyon F-69007, France.
Immunity
|September 16, 2008
Summary
Plasmacytoid dendritic cells (pDCs) are crucial for oral tolerance, preventing immune responses to food antigens. These cells induce systemic tolerance by suppressing T cell activity, highlighting their therapeutic potential for inflammatory diseases.
Area of Science:
- Immunology
- Cell Biology
Background:
- Oral tolerance prevents sensitization to dietary antigens and hypersensitivity.
- Plasmacytoid dendritic cells (pDCs) role in oral tolerance is not fully understood.
Purpose of the Study:
- Investigate the role of pDCs in oral tolerance.
- Determine if pDCs mediate systemic tolerance to CD4(+) and CD8(+) T cell-mediated delayed-type hypersensitivity (DTH) responses.
Main Methods:
- Systemic depletion of pDCs in mice.
- Antigen feeding studies.
- Transfer of antigen-loaded liver pDCs to recipient mice.
Main Results:
- Systemic depletion of pDCs abrogated oral tolerance induction.
- Transfer of pDCs induced antigen-specific suppression of T cell responses.
- pDCs induced T cell anergy or deletion via a CD4(+) T cell-independent mechanism.
Conclusions:
- pDCs are essential for oral tolerance induction and maintenance.
- pDCs present antigens to T cells, leading to systemic tolerance.
- pDCs represent a potential therapeutic target for inflammatory diseases.
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