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Calicivirus shedding in children after recovery from diarrhoeal disease

Carl D Kirkwood1, Rick Streitberg

  • 1Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia. carl.kirkwood@mcri.edu.au

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|September 16, 2008
PubMed

Insights

Human norovirus can be shed by children for extended periods, up to 100 days, after illness. This prolonged shedding increases the risk of community transmission, impacting public health strategies for acute gastroenteritis control.

Area of Science:

  • Virology
  • Public Health
  • Pediatrics

Background:

  • Human norovirus is a leading cause of acute gastroenteritis across all age groups.
  • Evidence indicates norovirus shedding can persist after symptom resolution, but shedding duration remains poorly understood.

Purpose of the Study:

  • To determine the duration of norovirus shedding in children following diarrhoeal illness.

Main Methods:

  • Prospective follow-up of 15 children for 18-36 months, collecting regular fecal specimens.
  • Utilized two distinct reverse transcription-polymerase chain reaction (RT-PCR) assays to detect norovirus.
  • Characterized norovirus isolates through sequence analysis.

Main Results:

  • Norovirus infections were detected in 8 out of 15 participating children.
  • Virus shedding was observed for at least 25 days in 3 children.
  • One child exhibited norovirus shedding for up to 100 days.

Conclusions:

  • Norovirus infections are frequently detected in children.
  • Norovirus carriage can persist significantly longer than previously documented.
  • Prolonged shedding suggests a greater potential for community transmission than previously recognized.
Abstract

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