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Updated: May 23, 2026

Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
Published on: April 2, 2013
[Frequency of seroreactors to Legionella among the patients with pulmonary infections]
1Department of Epidemiology, Nanjing Railway Medical College.
Abstract:
A prospective study was conducted with patients with pulmonary infections who were consecutively admitted to the three community hospitals in Benghu from July 1986 to May 1987, and to the children's hospital in Nanjing from September 1986 to January 1987. Antibodies to Lpi-8, Lm, Ld, and Lg were measured by the micro-agglutination test. During the study period, 150 adult patients (100 pairs sera) and 212 control healthy people and 110 pairs sera of childhood patients and 173 children without respiratory tract infections were investigated. The diagnosis of legionellosis was based on seroconversion (fourfold rise in titer to greater than 1:32 or static titer of greater than 1:32) and clinical and radiographic features of legionnaires' disease. About 11% legionella infection in hospitalized adult patients with pulmonary infections, and about 5.45% in children with atypical pneumonias.
Insights
Legionella infection was detected in 11% of adult pulmonary infection patients and 5.45% of children with atypical pneumonia. This study highlights the prevalence of Legionella in respiratory infections.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Epidemiology
Context:
- Prospective study conducted in community hospitals in Benghu and a children's hospital in Nanjing.
- Investigated adult patients with pulmonary infections and children with atypical pneumonias.
- Included healthy control groups for comparison.
Purpose:
- To determine the prevalence of Legionella infection in patients with pulmonary infections.
- To measure antibody titers against specific Legionella serogroups (Lpi-8, Lm, Ld, Lg).
- To diagnose legionellosis based on serological, clinical, and radiographic criteria.
Summary:
- Antibodies to Legionella were measured using the micro-agglutination test.
- Seroconversion or high static antibody titers indicated Legionella infection.
- Approximately 11% of adult patients and 5.45% of pediatric patients showed evidence of Legionella infection.
Impact:
- Provides data on the prevalence of Legionella in specific patient populations.
- Contributes to understanding the epidemiology of legionellosis in different geographic regions.
- Informs clinical diagnosis and public health strategies for respiratory infections.
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