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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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Published on: May 7, 2019

Hyperacute rejection of living related kidney grafts caused by endothelial cell-specific antibodies: case reports

B Grandtnerová1, N Mäcková, B Hovoricová

  • 1Transplant Centre, Faculty Hospital, Martin, Slovakia. grandtnerova_barbara@stonline.sk

Transplantation Proceedings
|September 16, 2008
PubMed

We describe two cases of hyperacute humoral rejection of living related kidney grafts despite negative pretransplantation T- and B-lymphocyte flow cytometric crossmatches and blood group identity. Retrospectively, antiendothelial IgG antibodies were detected on a panel of umbilical cord cells in the first case, and IgM antibodies against donor endothelial precursor cells were detected using a new endothelial cell crossmatch kit in the second case. Standard crossmatch methods using donor lymphocytes failed to detect these pathogenic antibodies and did not predict the danger of hyperacute rejection.

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