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Updated: Jul 1, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury and dialysis in children: illustrative cases
Jordan M Symons1, Stefano Picca
1Division of Pediatric Nephrology, Children's Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, WA 98105-0371, USA. jordan.symons@seattlechildrens.org
Insights
This study presents four case scenarios detailing the complex care of children with acute kidney injury (AKI) requiring renal replacement therapy. It emphasizes the interdisciplinary approach needed for optimal management in pediatric nephrology and critical care settings.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Renal Replacement Therapy
Background:
- Children with acute kidney injury (AKI) present a complex and diverse patient population.
- Effective management of pediatric AKI often necessitates specialized care, including renal replacement therapy (RRT).
- Collaboration between pediatric nephrologists and critical care physicians is crucial for addressing varied patient needs.
Observation:
- Four detailed case scenarios were developed to illustrate the challenges in pediatric AKI care.
- These scenarios highlight the heterogeneity in epidemiology and clinical presentations.
- The cases underscore the need for a multidisciplinary approach to treatment.
Findings:
- The case studies demonstrate significant challenges in providing optimal care for children with AKI.
- An interdisciplinary strategy is essential for successful management and improved patient outcomes.
- The scenarios serve as a foundation for understanding complex pediatric renal care.
Implications:
- This work informs the specialized care required for pediatric acute kidney injury.
- It emphasizes the critical role of collaboration in managing critically ill children with kidney disease.
- The presented cases guide further research and clinical practice in pediatric nephrology and critical care.
Abstract:
Pediatric nephrologists and critical care physicians are faced with a heterogeneous patient population with varied epidemiology caring for children with acute kidney injury or other diseases that may require renal replacement therapy provision. We have composed 4 detailed case scenarios to highlight the challenges and interdisciplinary approach required for optimal care provision to children, and that serve to direct the different articles contained in this special issue of Seminars of Nephrology devoted to acute kidney injury in children.
Related Concept Videos
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology
Chronic Kidney Disease III: Interprofessional Care

