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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: Jul 1, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Paraneoplastic glomerular diseases and malignancies.

Justine Bacchetta1, Laurent Juillard, Pierre Cochat

  • 1Reference Centre for Rare Renla Diseases, Hôpital Femme Mère Enfant, Bron F-69600, France. j.bacchetta@laposte.net

Critical Reviews in Oncology/Hematology
|September 16, 2008
PubMed
Summary

Paraneoplastic glomerulopathies, rare kidney diseases linked to cancer, often present as nephrotic syndrome. Early cancer treatment and supportive care are crucial for managing these conditions.

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Murine Bilateral Renal Lymphadenectomy
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Murine Bilateral Renal Lymphadenectomy

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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

  • Nephrology
  • Oncology
  • Pathology

Background:

  • Paraneoplastic glomerulopathies are uncommon kidney disorders associated with cancer.
  • They must be differentiated from iatrogenic renal damage.
  • Solid tumors are linked to membranous nephropathy, while Hodgkin's lymphoma is associated with minimal change disease.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and management of paraneoplastic glomerulopathies.
  • To highlight the importance of cancer treatment in managing these renal conditions.
  • To identify gaps in knowledge and suggest future research directions.

Main Methods:

  • Review of existing literature on paraneoplastic glomerulopathies.
  • Analysis of associations between specific cancers and glomerular diseases.
  • Discussion of diagnostic criteria and treatment strategies.

Main Results:

  • Carcinomas of the lung and gastrointestinal tract are common associated neoplasms.
  • Nephrotic syndrome is the most frequent and prognostically critical presentation.
  • Renal biopsy is recommended for patients with proteinuria and cancer, considering prognosis and treatment options.

Conclusions:

  • Primary cancer treatment is essential for managing paraneoplastic glomerulopathies.
  • Symptomatic treatment and complication prevention (thrombosis, infection) are vital.
  • Further epidemiologic and mechanistic studies are needed to understand prevalence and pathophysiology.