Related Experiment Video
Updated: Jul 1, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Genetic variation of Omi/HtrA2 and Parkinson's disease
Owen A Ross1, Alexandra I Soto, Carles Vilariño-Güell
1Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, United States. ross.owen@mayo.edu
Abstract:
Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.
Related Concept Videos
Parkinson Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Parkinson's Disease: Overview
Genetic Variation
Genes exist in different versions called alleles, which...
Single Nucleotide Polymorphisms-SNPs
