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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...

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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

OKCAM: an ontology-based, human-centered knowledgebase for cell adhesion molecules.

Chuan-Yun Li1, Qing-Rong Liu, Ping-Wu Zhang

  • 1Molecular Neurobiology Branch, NIH-IRP (NIDA), Baltimore, MD 21224, USA.

Nucleic Acids Research
|September 16, 2008
PubMed
Summary
This summary is machine-generated.

This study compiles 496 human cell adhesion molecules (CAMs) into six families, creating a comprehensive knowledgebase. It details their functions, expression, and links to human diseases, aiding future research.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Cell adhesion molecules (CAMs) are crucial for cell communication, development, and tissue plasticity.
  • CAMs play vital roles in brain development and neuronal connections.
  • Genetic variants in CAMs are associated with various diseases, including psychiatric, neurologic, and developmental disorders.

Purpose of the Study:

  • To systematically enumerate human CAM genes and document their global features.
  • To develop a comprehensive CAM knowledgebase (OKCAM) for accessible data and ontologic information.
  • To identify functional enrichment, regulation patterns, and disease associations of CAMs.

Main Methods:

  • Manual curation of protein domain structures and Gene Ontology annotations.
  • Utilizing 1487 NCBI Entrez annotations for gene compilation.
  • Mapping compiled CAM genes onto a detailed cell adhesion molecule ontology (850 terms).

Main Results:

  • Compilation of 496 human CAM genes across six families.
  • Development of the OKCAM knowledgebase (http://okcam.cbi.pku.edu.cn).
  • Identification of global CAM properties, including functional enrichment, expression patterns, and links to Mendelian and complex human diseases.

Conclusions:

  • The study provides the first systematic enumeration and global feature analysis of human CAMs.
  • The OKCAM knowledgebase offers a valuable resource for studying CAMs and their roles in health and disease.
  • Findings highlight the significance of CAMs in various biological processes and human pathologies.