Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current issues in neonatal herpes simplex virus infection.

P Toltzis1

  • 1Case Western Reserve University School of Medicine, Cleveland, Ohio.

Clinics in Perinatology
|June 1, 1991
PubMed
Summary

Neonatal herpes simplex virus (HSV) infection is severe. This review analyzes antenatal screening failures, clinical signs, immune factors, and antiviral therapy controversies for better newborn herpes management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colonization with antibiotic-resistant Gram-negative bacilli in the neonatal intensive care unit.

Minerva pediatrica·2003
Same author

Infection control in pediatric hospitals.

Current opinion in infectious diseases·2002
Same author

Etiology of fever and opportunities for reduction of antibiotic use in a pediatric intensive care unit.

Infection control and hospital epidemiology·2001
Same author

Molecular epidemiology of antibiotic-resistant gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period.

Pediatrics·2001
Same author

Nosocomial acquisition and transmission of antibiotic-resistant gram-negative organisms in the pediatric intensive care unit.

The Pediatric infectious disease journal·2001
Same author

Human immunodeficiency virus (HIV)-related risk-taking behaviors in women attending inner-city prenatal clinics in the mid-west.

Journal of perinatology : official journal of the California Perinatal Association·2000

Area of Science:

  • Neonatal infectious diseases
  • Virology
  • Maternal-fetal medicine

Background:

  • Herpes simplex virus (HSV) infection in newborns is a severe condition with significant morbidity and mortality.
  • Despite advances, challenges remain in its recognition and management.
  • Antenatal screening and treatment protocols require ongoing evaluation.

Purpose of the Study:

  • To review current challenges and controversies in neonatal herpes simplex disease.
  • To analyze the effectiveness of antenatal screening for HSV in high-risk pregnancies.
  • To discuss clinical presentations, immune determinants, and therapeutic strategies for neonatal herpes.

Main Methods:

  • Literature review of current issues in neonatal herpes simplex disease.
  • Analysis of factors influencing antenatal screening efficacy.
  • Discussion of clinical manifestations, immunological aspects, and antiviral treatment controversies.

Main Results:

  • Antenatal screening programs often fail to identify all high-risk pregnancies for neonatal HSV.
  • Neonatal herpes presents with diverse clinical manifestations, both typical and atypical.
  • Maternal and infant immune status significantly impacts disease presentation and therapeutic approaches.
  • Controversies persist regarding optimal antiviral therapy regimens and duration.

Conclusions:

  • Improved strategies are needed to enhance antenatal detection of HSV risk.
  • Comprehensive understanding of clinical and immunological factors is crucial for effective management.
  • Further research and consensus are required to address controversies in antiviral treatment for neonatal herpes.

Related Experiment Videos