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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Hemoglobin concentrations are closely linked to renal function in patients with type 1 or 2 diabetes mellitus

Gunter Wolf1, Nicolle Müller, Wilgard Hunger-Battefeld

  • 1Klinik für Innere Medizin III, Klinikum der Friedrich-Schiller-Universität, Jena, Germany. Gunter.Wolf@med.uni-jena.de

Kidney & Blood Pressure Research
|September 16, 2008
PubMed

Insights

Anemia is common in diabetes patients, affecting 17% with type 1 and 14% with type 2. Good kidney function and low protein in urine correlate with higher hemoglobin (Hb), but metabolic control showed no negative impact.

Area of Science:

  • Nephrology
  • Endocrinology
  • Hematology

Background:

  • Anemia is frequently observed in patients with diabetes mellitus.
  • Anemia can manifest early in the course of diabetes.

Purpose of the Study:

  • To evaluate hemoglobin (Hb) levels in patients with type 1 and type 2 diabetes.
  • To determine correlations between Hb and various clinical parameters in diabetic patients.

Main Methods:

  • Hb values were analyzed in 751 patients with type 1 diabetes and 3,306 patients with type 2 diabetes.
  • Correlations were assessed for Hb with metabolic control (HbA1c, blood glucose), renal function (eGFR, creatinine, albuminuria, proteinuria), leukocytes, diabetes duration, and ACE inhibitor/AT1-receptor antagonist use.

Main Results:

  • Anemia prevalence was 17% in type 1 and 14% in type 2 diabetes patients.
  • Positive correlation found between Hb and estimated glomerular filtration rate (eGFR).
  • Negative correlations observed between Hb and albuminuria, proteinuria, and serum creatinine.

Conclusions:

  • No adverse effects of metabolic control (HbA1c, blood glucose) on Hb levels were demonstrated.
  • Renal function parameters (eGFR, albuminuria, proteinuria, creatinine) showed significant associations with Hb levels.
Abstract

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