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EBV and CMV in chronic periodontitis: a prevalence study
Maryam Chalabi1, Sharareh Moghim, Ahamad Mogharehabed
1Medical Biology Research Center, P.O Box 1568, sorkheh ligeh, Kermanshah, Iran. mchalabi@kums.ac.ir
Archives of Virology
|September 16, 2008
Summary
This study found Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are common in periodontitis plaque. Their presence was not linked to bleeding on probing in patients.
Area of Science:
- Oral microbiology
- Infectious diseases
- Virology
Background:
- Periodontitis is an infectious oral disease.
- Herpesviruses, including Epstein-Barr virus (EBV) and cytomegalovirus (CMV), are suspected to play a role in periodontitis pathogenesis.
Purpose of the Study:
- To investigate the prevalence of EBV and CMV in subgingival and supragingival plaque.
- To determine if EBV and CMV presence correlates with clinical indicators of periodontitis severity.
Main Methods:
- Nested polymerase chain reaction (PCR) was employed to detect EBV and CMV.
- Clinical parameters including clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were assessed.
- The study included 61 patients with chronic periodontitis and 40 healthy controls.
Main Results:
- The prevalence of EBV-1, EBV-2, and CMV in plaque samples was 73.8%, 4.9%, and 59%, respectively.
- No significant association was found between the presence of EBV-1, EBV-2, or CMV and bleeding on probing (BOP).
Conclusions:
- EBV and CMV are frequently detected in the oral plaque of individuals with chronic periodontitis.
- The study did not establish a direct link between these herpesviruses and the inflammatory response indicated by bleeding on probing.
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