Related Experiment Videos
Intercellular adhesion molecule-1 gene K469E polymorphism and ischemic stroke: a case-control study in a Chinese
Xiao Xia Li1, Jian Ping Liu, Jin Quan Cheng
1Department of Epidemiology and Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China.
Molecular Biology Reports
|September 16, 2008
Summary
The Intercellular Adhesion Molecule-1 (ICAM-1) K469E polymorphism is linked to ischemic stroke (IS) risk, particularly in females. This genetic variation may play a role in the disease
Area of Science:
- Genetics
- Neurology
- Cardiovascular Disease
Background:
- Intercellular adhesion molecule-1 (ICAM-1) is implicated in ischemic stroke (IS) pathogenesis.
- Gene-gender interactions influence blood pressure, a major IS risk factor.
Purpose of the Study:
- To investigate the association between ICAM-1 K469E polymorphism and IS.
- To determine if this association differs between sexes.
Main Methods:
- A 1:1 case-control study involving 309 Chinese IS patients and 309 controls.
- ICAM-1 K469E polymorphism analyzed using PCR and restriction enzyme analysis.
Main Results:
- ICAM-1 K469E polymorphism showed a significant association with IS.
- The 469E genotypes were significantly associated with IS in females, but not males.
- Female sex and ICAM-1 EK/EE genotypes interacted significantly, increasing IS risk (OR = 3.54, P = 0.001).
Conclusions:
- The ICAM-1 469E allele may contribute to ischemic stroke pathogenesis.
- This genetic factor appears particularly relevant in females, with a lesser role in males.
