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Related Experiment Video

Updated: Jul 1, 2026

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
11:28

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

Insights into Langerhans cell function from Langerhans cell ablation models.

Daniel H Kaplan1, Adrien Kissenpfennig, Björn E Clausen

  • 1Department of Dermatology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. DanKaplan@umn.edu

European Journal of Immunology
|September 16, 2008
PubMed
Summary

Langerhans cells (LCs) in skin immunity are explored using novel mouse models. These models allow tracking and depletion of LCs, clarifying their role in skin immune responses and comparing them with dermal dendritic cells (DCs).

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Langerhans cells (LCs) are key immune cells in the skin's epidermis.
  • Their exact role in initiating and controlling skin immune responses is under investigation.
  • Recent studies question their traditional role as sentinel dendritic cells (DCs).

Purpose of the Study:

  • To investigate the precise role of LCs in regulating skin immunity.
  • To compare LCs with other dermal dendritic cell populations.
  • To analyze recent data on LC function in cutaneous immune responses.

Main Methods:

  • Generation of genetically modified mouse models for in vivo LC tracking and depletion.
  • Utilizing enhanced green fluorescent protein (eGFP) for LC visualization.

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Last Updated: Jul 1, 2026

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
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Published on: February 28, 2018

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  • Comparative analysis of inducible and constitutive LC depletion models.

    • Main Results:

    • The study highlights similarities and differences between various mouse models for studying LCs.
    • It discusses the discovery and functional importance of Langerin-positive dermal DCs.
    • Recent data provides new insights into the function of LCs in the skin.

    Conclusions:

    • Genetically modified mouse models are crucial for dissecting LC function in vivo.
    • Understanding LC and dermal DC roles is vital for skin immunity research.
    • Further investigation is needed to fully elucidate LC contributions to skin immune regulation.