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Updated: Jul 1, 2026
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Pleiotropic function of FGF-4: its role in development and stem cells
Nobuyoshi Kosaka1, Hiromi Sakamoto, Masaaki Terada
1Section for Studies on Metastasis, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
Summary
Fibroblast growth factor-4 (FGF-4) regulates development and stem cell functions. This review explores FGF-4
Area of Science:
- Biochemistry
- Molecular Biology
- Developmental Biology
Background:
- Fibroblast growth factors (FGFs) are crucial regulators of diverse biological functions.
- The FGF superfamily, including FGF-4, exhibits varied interactions with FGF ligands and receptors.
- FGF-4 is a potent mitogen involved in development, morphogenesis, and various biological processes.
Purpose of the Study:
- To review the diverse biological functions of FGF-4 in developmental processes.
- To discuss the putative roles of FGF-4 in stem cell biology.
Main Methods:
- Literature review of recent studies on FGF-4 gene regulation.
- Analysis of FGF-4's role in mammalian cell molecular mechanisms.
- Examination of FGF-4's effects on stem cell proliferation and differentiation.
Main Results:
- FGF-4 plays a significant role in mammalian cell molecular mechanisms during development.
- FGF-4 regulates proliferation and differentiation in embryonic and tissue stem cells.
- The review highlights the diverse functions of FGF-4 in development and stem cell biology.
Conclusions:
- FGF-4 is a key regulator in developmental processes and stem cell biology.
- Understanding FGF-4's mechanisms provides insights into development and regenerative medicine.
- Further research into FGF-4 functions can unlock new therapeutic strategies.
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