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Related Experiment Videos

Verapamil and ventricular tachycardias.

Y T Tai1, W H Chow, C P Lau

  • 1Department of Medicine, University of Hong Kong.

Chinese Medical Journal
|July 1, 1991
PubMed
Summary

Verapamil, a calcium channel blocker, can effectively treat certain types of ventricular tachycardia, particularly idiopathic fascicular and catecholamine-mediated VT, challenging previous assumptions about its use in wide QRS tachycardias.

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Ventricular tachycardias (VT) in structural heart disease typically do not respond to verapamil.
  • Verapamil is effective for supraventricular tachycardias (SVT).
  • Intravenous verapamil is sometimes used diagnostically/therapeutically for wide QRS tachycardias.

Purpose of the Study:

  • To report two unusual cases of verapamil-sensitive ventricular tachycardia.
  • To highlight fascicular and catecholamine-mediated VT as verapamil-responsive idiopathic VT subtypes.
  • To review the risks associated with verapamil for wide complex tachycardias.

Main Methods:

  • Case report of two patients with verapamil-sensitive ventricular tachycardia.
  • Review of literature on verapamil use in wide QRS tachycardias.
  • Analysis of specific VT mechanisms (fascicular, catecholamine-mediated).

Main Results:

  • Two cases of ventricular tachycardia responsive to verapamil were identified.
  • These cases represent fascicular and catecholamine-mediated idiopathic VT.
  • Verapamil's efficacy in these specific VT types was demonstrated.

Conclusions:

  • Certain idiopathic ventricular tachycardias, specifically fascicular and catecholamine-mediated types, can be sensitive to verapamil.
  • This sensitivity contrasts with the general non-responsiveness of VT in structural heart disease.
  • Careful consideration and risk assessment are necessary when using verapamil for wide complex tachycardias.

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