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Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Unrenewable Cells00:50

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Jul 1, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Alopecia areata in children.

Faris Hawit1, Nanette B Silverberg

  • 1Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.

Cutis
|September 17, 2008
PubMed
Summary

Alopecia areata is an autoimmune skin condition causing patchy hair loss. This overview focuses on treatment options for pediatric alopecia areata, addressing its emotional impact on children.

Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Pediatrics

Background:

  • Alopecia areata (AA) is a T-cell mediated autoimmune disorder.
  • It characteristically presents as nonscarring hair loss, primarily affecting the scalp.
  • Patchy hair loss is the most common clinical manifestation.

Purpose of the Study:

  • To provide a concise overview of childhood alopecia areata.
  • To specifically focus on the therapeutic strategies available for pediatric AA.
  • To acknowledge the significant emotional distress associated with severe forms of childhood AA.

Main Methods:

  • Literature review of existing therapeutic options for pediatric alopecia areata.
  • Synthesis of current treatment guidelines and emerging therapies.

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Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

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A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
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Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

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  • Focus on nonscarring alopecia management in children.

    • Main Results:

    • Overview of various treatment modalities for childhood alopecia areata.
    • Discussion of efficacy and safety profiles of different therapies.
    • Highlighting the importance of a multidisciplinary approach.

    Conclusions:

    • Effective management of childhood alopecia areata requires tailored therapeutic strategies.
    • Addressing the psychological impact is crucial for improving quality of life.
    • Ongoing research is vital for advancing treatment options for pediatric hair loss disorders.